Effects of Intravenous Recombinant Human Brain Natriuretic Peptide on Ventricular Remodeling and Ventricular Systolic Synchrony in Acute Myocardial Infarction Patients After Percutaneous Coronary Intervention
10.3969/j.issn.1000-3614.2009.03.004
- VernacularTitle:静脉应用重组人B-型利钠肽对急性心肌梗死冠状动脉介入术后心室重塑和收缩同步性的影响
- Author:
Ling XUE
;
Xianghua FU
;
Weili WU
;
Xinshun GU
;
Qing MIAO
;
Yunfa JIANG
;
Qingmin WEI
- Publication Type:Journal Article
- Keywords:
Recombinant human brain natriuretic peptide;
Acute myocardial infarction;
Percutaneous coronary intervention;
Ventricular remodeling;
Ventricular systolic synchrony.
- From:
Chinese Circulation Journal
2009;24(3):170-173
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the influence of recombinant human brain natriuretic peptide(rhBNP)on ventricular remodeling and ventricular systolic synchrony in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI).Methods: A total of 48 patients with AMI after PCI were randomized into two groups: rhBNP Group (n=25) and Routine treatment Group (n=23).Two dimension echocardiography was used to measure the index of left ventricular end-diastolic volume (LVEDVI), the index of left ventricular end-systolic volume (LVESVI), left ventricular ejection fraction (LVEF), the index of left ventricular mass (LVMI), the movement index of infarcted regional wall (RWMI) at 1 week, 4 weeks and 24 weeks after the treatment procedure.And at 1 week and 24 weeks period, equilibrium radionuclide angiography was performed respectively to evaluate the ventricular systolic synchrony.Results: ①1 week after PCI, LVESVI in rhBNP group was decreased and LVEF was increased than that in Routine treatment group (P<0.05, respectively).4 and 24 weeks after PCI, LVEDVI, LVESVI, LVEF were significantly different in rhBNP group than those in Routine treatment group (P<0.05,respectively).24 weeks after PCI, RWMI and LVMI were significantly decreased in rhBNP group than those in Routine treatment group(P<0.05,respectively).②24 weeks after PCI, phase shift, full width at half maximum and peak phase standard deviation were significantly improved in rhBNP group than those in Routine treatment group (P<0.05, respectively).Conclusion: Intravenous injection of rhBNP could inhibit left ventricular remodeling and improve left ventricular function.
