Effect of "Qishen Yiqi Droplet"on Inflammatory Factors in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention
10.3969/j.issn.1000-3614.2009.03.007
- VernacularTitle:芪参益气滴丸对急性冠脉综合征患者冠状动脉介入治疗术后炎症趋化因子水平的影响
- Author:
Wanlin WEI
;
Wei ZHANG
;
Tianlong ZHANG
;
Guoxiang TIAN
;
Qingyi MENG
;
Yanling ZHANG
;
Yanming SUN
- Publication Type:Journal Article
- Keywords:
Qishen Yiqi Droplet;
Acute coronary syndrome;
Percutaneous coronary intervention;
High sensitivity C reactive protein;
Plasminogen activator inhibitor-1;
Endothelin-1
- From:
Chinese Circulation Journal
2009;24(3):182-184
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of "Qishen Yiqi Droplet" on serum concentrations of high sensitivity C reactive protein(hs-CRP),plasminogen activator inhibitor-1(PAI-1),endothelin-1(ET-1)in patients with acute coronary syndrome(ACS)after percutaneous coronary intervention (PCI).Methods:A total of 100 consecutive ACS patients ready to receive PCI therapy in our hospital from june 2007 to August 2008 were randomly assigned into two groups:Qishen group,n=50,with Qishen Yiqi Droplet 5.0 g three timee a day+conventional therapy after PCI;and Control group,n=50 with conventional therapy after PCI.The concentrations of hs-CRP,PAI-1 and ET-1were detected and compared 24 hours before PCI,and 24 hours,4weeks after PCI between two groups respectively.Results:There were no obvious differences of hs-CRP,PAI-1 and ET-1 24 hours after PCI in two groups.The levels of hs-CRP,PAI-1,ET-1 were lower in Qishen group than in Control group 4 weeks after PCI (0.219±0.143)ng/dl vs.(0.366±0.132)ng/dl,P<0.001,(104.252±26.038)ng/dl vs.(118.419±28.849)ng/ml,P<0.05,and (37.411±12.977)ng/dl vs.(45.755±12.305)pg/ml,P<0.01,respectively.Conclusion:Qishen Yiqi Droplet could decrease the levels of hs-CRP,PAI-1 and ET-1 in ACS patients who underwent PCI,and it might have the protective role in preventing the neointimal hyperplasia and thrombogenesis after stent implantation.
