Relationship Between Serum Resistin and Carotid Intima Media Thickness in Patients With Essential Hypertension
10.3969/j.issn.1000-3614.2009.03.015
- VernacularTitle:高血压患者血清抵抗素水平与颈动脉内膜-中层厚度的相关性研究
- Author:
Xuliang LI
;
Xianmei WANG
;
Lixia YANG
;
Jing ZHOU
;
Chuanming GUO
;
Feng QI
;
Liyong WU
;
Xiaodong ZHANG
- Publication Type:Journal Article
- Keywords:
Resistin;
Carotid intima media thickness;
Hypertension4
- From:
Chinese Circulation Journal
2009;24(3):213-216
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the relationship between serum resistin levels and carotid intima media(IMT)thickness in patients with essential hypertension. Methods:This study consisted of 272 patients with essential hypertension. The patients were divided into three groups according to their serum resistin levels. Group 1,n=91,serum resistin level 1.233-3.701 ng/ml;Group 2,n=91,serum resistin level 3.728-8.777 ng/ml;and Group 3,n=90,serum resistin level 8.809-28.658 ng/ml. Results:The carotid IMT and maximum carotid IMT of Group 3 were the highest in three groups.(P＜0.05).As shown in multivariate analysis for factors affecting carotid IMT,serum resistin level(β=0.220,t=5.793,P=0.000)was independently associated with the carotid IMT after controlling the age,blood glucose,uric acid,low-density lipoprotein cholesterol,systolic blood pressure and diastolic blood pressure. Serum resistin level(β=0.189,t=4.733,P=0.000)was independently associated with the maximum carotid IMT after controlling the age,blood glucose,body mass index,diastolic blood pressure,diabetes mellitus,high sensitivity C reactive protein,total cholesterol and triglyceride. Conclusion:Serum resistin was independently associated with the increased carotid IMT in essential hypertension patients.
