Association between survivin promoter -31C/G polymorphism and genetic susceptibility to sporadic colorectal cancer
- VernacularTitle:survivin基因启动子区-31C/G多态性与散发性结直肠癌遗传易感性的关系
- Author:
Jun HUANG
;
Jianping WANG
;
Lei WANG
;
Huanliang LIU
;
Yisheng WEI
;
Meijin HUANG
;
Xinhui FU
;
Jing CHEN
;
Dianke CHEN
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Genes,survivin;
Polymorphism,single nucleotide
- From:
Chinese Journal of Pathophysiology
2009;25(12):2344-2348
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the association between -31C/G polymorphism in the promoter of survivin gene and the susceptibility to sporadic colorectal cancer (CRC) in southern Chinese population. METHODS: survivin -31C/G genotypes were determined by PCR-RFLP in 711 healthy controls and 702 CRC cases. RESULTS: The number of CRC patients carrying with CC genotype was much higher than that of controls (36.5 % vs 26.2%,χ~2 =17.89,P<0.01). Compared to CC genotypes, CG, GG genotypes and G allele carriers had a significantly decreased risk of CRC, with the decrease being 0.61-fold (95% confidence interval=0.46-0.80, P<0.01), 0.52-fold (95% confidence interval=0.38-0.71,P<0.01) and 0.58-fold (95% confidence interval=0.45-0.74, P<0.01), respectively. CONCLUSION: survivin gene -31C/G polymorphism is associated with sporadic CRC risk, the G variant genotype is the independent protective factors against sporadic CRC in southern Chinese population.
