The Influence of Recombinant Human α-2b Interferon Capsule for Vaginal Foams on the Negative Conversion Rate of HPV
- VernacularTitle:重组人干扰素α-2b阴道泡腾胶囊影响HPV转阴率的临床分析
- Author:
Yanxiang CHENG
;
Jinghong JIANG
;
Xuexian XU
- Publication Type:Journal Article
- Keywords:
Interferon;
Human papilloma virus;
Negative conversion rate;
Immune
- From:
Journal of Practical Obstetrics and Gynecology
2009;25(12):733-735
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect and mechanism of Xinfuning( recombinant human α-2b interferon capsule for vaginal foams) on the clearance of human papilloma virus (HPV). Methods: The patients with HPV infection were divided into experimental group (Xinfuning group) and control group (Shurunshuan group, a common recombinant human interferon α-2b in suppository form) .The HPV negative conversion rate was compared between the two groups after action on vaginal posterior fomix. The content of cytokines IL-4, IL-10, IFN-γ, TNF-a in the cervical region before or after the application was detected by ELISA. Results:The negative conversion rate in the experimental group was higher than that in the control group ( P<0.05). The content of IL-4, IL-10 was decreased and the cont ent of IFN-γ,TNF-α was increased apparently( P < 0.05). Conclusions: Interferon has the effect on clearance of HPV infection by regulating Th1/Th2 balanced state to boost immunization and the unique preparation of Xinfuning can strengthen such function.
