Autophagy and myocardial ischemia/reperfusion injury
- VernacularTitle:自噬与心肌缺血/再灌注损伤
- Author:
Youbin LIU
;
Shusen YANG
;
Ying FAN
;
Runtao GAN
- Publication Type:Journal Article
- Keywords:
Autophagocytosis;
Myocardial ischemia;
Reperfusion injury;
Signal transduction
- From:
Chinese Journal of Pathophysiology
2009;25(12):2478-2482
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a lysosome-dependent degradative pathway which is characterized by cytoplasmic vacuolization. However, it is not just a simple degradative pathway. Research shows that autophagy is related to many diseases, such as neurodegenerative disease, malignant tumor, ageing, pathogenic microorganism infection, myocardial ischemia/reperfusion injury and so on. Autophagy exactly exists in myocardial ischemia/reperfusion injury, and it becomes a new research hotspot. This review will focus on the occurrence and development of autophagy and its role, signal transduction and research status in myocardial ischemia/reperfusion injury.
