Function and significance of integrin-linked kinase in heart
- VernacularTitle:整合素连接激酶在心脏中的功能意义
- Author:
Yaosheng WANG
;
Xiaoshu CHENG
- Publication Type:Journal Article
- Keywords:
Integrin-linked kinase;
Cardiac hypertrophy;
Cardiomyopathy,congestive;
Myocarditis;
Myocardial infarction;
Signal transduction pathway
- From:
Chinese Journal of Pathophysiology
2009;25(12):2483-2486
- CountryChina
- Language:Chinese
-
Abstract:
Integrin-linked kinase (ILK) is a widely expressed protein kinase that relate to cellular growth and differentiation. It is most abundant in the heart. Recently, many researches revealed that ILK is highly relevant to cardiac response to biomechanical stresses. Also, ILK plays important roles in regulation of the occurrence and development of cardiac hypertrophy, dilated cardiomyopathy, viral myocarditis and myocardial senescence via correlation to several classical signal transduction pathway. Meanwhile, ILK functions in protection after myocardial infarction. This article will try to summarize the effects and relevant mechanism of ILK in above-mentioned aspects, overall reveals the roles of ILK in heart and its potential clinical significance.
