Research progress in the relationship of autocrine motility factor,autocrine motility factor receptor and the nervous system
- VernacularTitle:自分泌运动因子及其受体与神经系统的关系研究进展
- Author:
Xuan SHAO
;
Xiaoli CHI
;
Wenxia ZHOU
;
Yongxiang ZHANG
- Publication Type:Journal Article
- Keywords:
autocrine motility factor;
autocrine motility factor receptor;
PD-I alpha;
neurodegeneration;
MORFO domain;
Alzheimer's Disease
- From:
Chinese Pharmacological Bulletin
2009;25(12):1541-1545
- CountryChina
- Language:Chinese
-
Abstract:
Autocrine motility factor (AMF) plays an important role in the stimulation of the migration and motility of cells, especially the generation, migration and angiogenesis of tumor. Recently, it has been found that AMF has three isoforms, ATX-t, ATX-m and PD-I alpha. The PD-I alpha isoform is specifically expressed in the brain, which plays extensive functions in nervous system, such as regulating neural development and differentiation, promoting neurotrauma repair, inducing neuropathic pain, even contributing neurodegeneration under some circumstances. This indicates the close relationship of AMF/AMFR and the pathophysiology of the nervous system. This paper mainly reviews the function of AMF and AMFR and its possible mechanism in the nervous system.
