The mediation of immune activation on serotonin and glutamate systems in pathological process of depression
- VernacularTitle:免疫激活对抑郁症谷氨酸和五羟色胺系统的调节
- Author:
Jianshu LOU
;
Xiaochun YANG
;
Jie FANG
;
Jianli PAN
;
Jianyou GUO
- Publication Type:Journal Article
- Keywords:
depression;
glutamate;
serotonin;
immune activation;
cytokine;
indoleamine 2,3-dioxygenase
- From:
Chinese Pharmacological Bulletin
2009;25(12):1555-1558
- CountryChina
- Language:Chinese
-
Abstract:
Immunological alterations and changes in neurotransmission are considered to be crucial in the pathological process of depression. An immune activation including increased production of proinflammatory cytokines has repeatedly been described in depression, which shines a clue for new anti-depression therapy. Immune activation will lead to depression through serotonin and glutamate systems. This paper is attempted to review the immune mediated alterations on serotonin and glutamate systems.
