Effects of Y-IP5 on morphine-induced behaviorals ensitization and conditioned place preference in mice
- VernacularTitle:Y-IP5对小鼠吗啡行为敏化和条件性位置偏爱的影响
- Author:
Yuefang XU
;
Ruibin SU
;
Rifang YANG
;
Ning WU
;
Xinqiang LU
;
Jin LI
- Publication Type:Journal Article
- Keywords:
Y-IP5;
NMDA;
NR2B;
morphine;
behavioral sensitization;
conditioned place preference
- From:
Chinese Pharmacological Bulletin
2009;25(12):1578-1583
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of Y-IP5 on morphine-induced behavioral sensitization and CPP in mice.Methods Locomotor activity was detected after Y-IP5 administration or co-administration of Y-IP5 with morphine in mice.Mice were treated with morphine to induce behavioral sensitization. Then the effects of Y-IP5 on the development, transfer and expression of morphine-induced behavioral sensitization were investigated. Mice were treated with morphine to induce CPP. Then the effect of Y-IP5 on the acquisition of morphine-induced CPP was studied.Results Y-IP5 itself didn′t influence locomotor activity of mice.Co-administration of Y-IP5 with morphine inhibited morphine-induced hyperactivity (P<0.05) and the development of morphine-induced behavioral sensitization in mice (P<0.05), however, did not influence the transfer and expression of morphine-induced behavioral sensitization.Co-administration of Y-IP5 with morphine also inhibited the acquisition of morphine-induced CPP (P<0.05).Conclusion Y-IP5 may inhibit the psychological dependence induced by morphine.
