Progress in Study on Animal Models of Polycystic Ovary Syndrome and Intervention with Traditional Chinese Medicine
- VernacularTitle:多囊卵巢综合征动物模型与中医药干预研究进展
- Author:
Yurong WANG
;
Yong TAN
- Publication Type:Journal Article
- Keywords:
Polycystic ovarian syndrome;
Animal model;
Traditional Chinese Medicine
- From:
Acta Laboratorium Animalis Scientia Sinica
2009;17(6):478-483
- CountryChina
- Language:Chinese
-
Abstract:
Polycystic ovary syndrome (PCOS) is a disease of dysgenesia and dysmetabolism. Its clinical manifestations include hyperandrogenism, ovulation failure, hyperinsulinemia, elevated serum LH level, obesity and sterility. Histological examination of ovary reveals polycystic changes. It is difficult to carry out clinical research because of its complicated pathogenesis, pathophysiology and multiple biochemical changes and clinical manifestations. It is necessary to study PCOS using animal models. In this article, the authors introduce some methods of establishing animal models of PCOS, such as androgen administration (including testosterone propionate,dehydroepiandrosterone), combination of insulin with HCG, use of estradiol valerate,combination of progestrone with HCG, aromatic cyclase inhibitor method,and so on, and review the effects of traditional Chinese medicine on the intervention of PCOS.
