The Relationship between the Clinicopathologic Characteristics of Triple Negative Breast Cancer and EGFR Expression
10.3969/j.issn.1000-8179.2010.01.009
- VernacularTitle:三阴性乳腺癌临床病理特点及与EGFR表达关系的探讨
- Author:
Ru JI
;
Jingyong LI
;
Xiulan ZHAO
;
Qiang GU
;
Jiangbo LI
;
Qiuyue DU
;
Yixin LIU
- Publication Type:Journal Article
- Keywords:
Triple negative breast cancer;
Clinicopathologic characteristic;
Prognosis;
EGFR
- From:
Chinese Journal of Clinical Oncology
2010;37(1):32-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the clinicopathologic characteristics and the prognostic factors of triple negative breast cancer,and to study the correlation between clinicopathologic features and EGFR expression.Methods:Clinical characteristics and prognosis of 200 breast cancer patients diagnosed between 1997 and 2004 were reviewed.The paraffin embedded tissues were selected and tissue microarray blocks were made.Immunohistochemical staining was used to evaluate the expression of ER,PR and HER2 for breast cancer molecular type.EGFR expression was evaluated to analyze its correlation with the clinical characteristics and prognosis.Results:Fourty-two cases(21%)of 200 were triple negative breast cancer(TNBC).There was no significant difference between TNBC and non-TNBC in clinicopathologic parameters such as age,tumor size,clinical stage,and lymph node status.However,there was significant difference in histological category and menostasis status between the two groups(P<0.05).Among TNBC,17 0f 42 died during the follow-up(the overall suivival rate was 59.52%),while 26 0f 158 non-TNBC died(the overall survival rate was 83.54%).EGFR was significantly overexpressed in TNBC(69.05%)and it was associated with lymph node status and histological category.Conclusion:Although the incidence of TNBC is low,it has a poorer prognosis than other subtypes.EGFR is highly expressed in TNBC and may serve as a prognostic index and an important therapatic target for breast cancer.
