Relationship of Tumor Necrosis Factor Genetic Polymorphisms with the Clinical Course and Outcome of Non-Hodgkin's Lymphoma
10.3969/j.issn.1000-8179.2010.01.007
- VernacularTitle:肿瘤坏死因子基因多态性与非霍奇金淋巴瘤临床与预后的相关研究
- Author:
Hongyun ZHAO
;
Xueyun ZHONG
;
Yunxian CHEN
- Publication Type:Journal Article
- Keywords:
Non-Hodgkin's lymphoma;
Tumor necrosis factor;
Gene polymorphism
- From:
Chinese Journal of Clinical Oncology
2010;37(1):23-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship of-308bp polymorphism in tumor necrosis factor-α (TNFa)gene and+252bp in lymphotoxin-α(LTα)gene with the clinical course and outcome of non-Hodgkin's lymphoma(NHL).Methods:The single base change in TNFα gene and LTα gene was analyzed among 96 Chinese patients with NHL and 72 normal controls by using PCR-restrictive fragment length polymorphism (RFLP).The clinical data were collected and survival analysis was performed.Results:In NHL patients,no statistcally significant association was found between the presence of a given TNF/LT haplotype status and clinical variables such as age,seX,disease stage,and so on.The patients carrying low-risk haplotype achieved a more sensitive response to first-line therapy than that in patients with high-risk haplotype(70.4%v 45.2%:P=0.018).The estimated 1-year progression-free survival rates in the high-risk and low-risk groups were 66.67% and 87.5%,respectively(log-rank test,P=0.0231).Kaplan-Meier method showed that the estimated 2-year and 4-year overall survival rates were 39.95%and 8.32%in patents carrying high-risk haplotypes and 65.13%and 46.52%in patients carrying low-risk haplotypes,respectively(log-rank test,P=0.0012).In multivariate Cox regression models.the TNF/LT haplotype status was found to be a dsk factor for outcome of NHL (P=0.034).Conclusion:There is an association between TNF/LT haplotype status and response to therapy and outcomes of NHL in Canton area,China.Detecting TNF/LT haplotype may be a sensitive method to evaluate the outcome of NHL.
