The Association of FGFR2 rs1219648 Polymorphism with Susceptibility of Breast Cancer in Han Population in Guizhou Province
10.3969/j.issn.1000-8179.2010.01.008
- VernacularTitle:贵州汉族人群乳腺癌与FGFR2 rs1219648多态性相关性研究
- Author:
Mei LIU
;
Keren SHAN
;
Yan HE
;
Ting ZHANG
;
Yan XIAO
;
Changxue WU
;
Chanjuan WANG
;
Xiaoliang WANG
;
Zhizhong GUAN
;
Xilin REN
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Fibroblast growth factor receptor 2 gene;
Single nucleotide polymorphism
- From:
Chinese Journal of Clinical Oncology
2010;37(1):29-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association between polymorphisms of FGFR2 and the susceptibility of breast cancer in Han population in Guizhou province.Methods:Genotyping was performed using PCR-sequence-specific primers(PCR-SSP)in 106 histologically confirmed breast cancer cases and 116 cancer-free controls.Results:The genotype frequencies of rs1219648 TT,TC,and CC were 50%,25.47%.and 24.53% in breast cancer cases and 29.31%,48.28%,and 22.41% in the controls.The gene frequencies of T in breast cancer cases and the controls were 62.74% and 53.45%.respectively.The gene frequencies of C were 37.26% and 46.55%.respectively.The distribution of allele and genotype frequencies of FGFR2 rs1219648 was statistically different between breast cancer cases and the controls(P<0.05).Conclusion:FGFR2 rs1219648 polymorphism influences the susceptibility of breast cancer.TT genotype might serve as a risk factor for breast cancer.
