A Preliminary Study on the Role of Mitochondrial Protein, Bcl-2 and Bax in Tumorigenesis
10.3969/j.issn.1000-8179.2009.24.009
- VernacularTitle:线粒体蛋白Bcl-2和Bax在肿瘤发生中作用的初步探讨
- Author:
Wenjing SONG
;
Xiaoyan CHEN
;
Xiulan ZHAO
;
Zenghui LIU
;
Baocun SUN
- Publication Type:Journal Article
- Keywords:
Mitochondria protein;
Tumor cell apoptosis;
Bcl-2;
Bax
- From:
Chinese Journal of Clinical Oncology
2009;36(24):1409-1411
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the expressions of mitochondrial protein (MAB1273), Bcl-2, and Bax in renal cell carcinoma and to investigate their role in the tumorigenesis. Methods: The expressions of mitochondrial protein, Bcl-2 and Bax were detected by immunohistochemistry SP method in 9 tissue samples of renal on-cocytoma, 6 samples of chromophobe carcinoma, 23 samples of clear cell carcinoma and 12 samples of normal renal tissue. Results: The expression of MAB1273 in renal oncocytoma, chromophobe carcinoma and clear cell carcinoma was much higher than that in normal renal tissue (P=0.006). No significant difference was found in MAB1273 expression among the three types of renal carcinoma. The expression of Bcl-2 was higher in the renal carcinoma groups than in the normal renal tissue group, with a significant difference (P=0.008). The expression of Bax was not different among all of the groups (P=0.057). Rank correlation analysis showed a positive correlation between MAB1273 and Bcl-2 expression (r=0.341, P=0.015). The expression of Bcl-2 was negatively correlated with Bax expression (r= -0.287, P=0.043). Conclusion: Overexpression of mitochondrial protein and Bcl-2 and underexpression of Bax may play a part in the genesis of renal oncocytoma, chromophobe carcinoma and the clear cell carcinoma, indicating that overexpression of MAB1273 may be correlated with apoptosis of renal cell carcinoma cells.
