Effects of nicardipine,urapidil,and esmolol on baroreflex sensitivity during induction in patients with essential hypertension
- VernacularTitle:尼卡地平、乌拉地尔和艾司洛尔对全麻诱导期间压力反射敏感性的影响
- Author:
Shuwen LI
;
Hongliang LIU
- Publication Type:Journal Article
- Keywords:
Anesthesia induction;
Baroreflex;
Nicardipine;
Urapidil;
Esmolol
- From:
The Journal of Clinical Anesthesiology
2009;25(12):1028-1030
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of nicardipine,urapidil,and esmolol on baroreflex sensitivity(BRS) in patients with essential hypertension(EH) during induction of general anesthesia.Methods EH patients were divided into four groups,who were given nicardipine 0.5μg/kg(group N,15 cases),urapidil 0.5 mg/kg(group U,16 cases),esmolol 0.25 mg/kg(group E,16 cases)or normal saline (group C,15 cases)at 2 min before induction.The induction of general anesthesia was performed with the same drugs.Sodium nitroprusside 50-100 μg was administered tomake systolic pressure(SBP)decreased by 15-25 mm Hg at different time points of before induction,before incubation,at 5,10,15,20 and 30 rain after intubation.The RR intervel on ECG was recor(ded and BRS was calculated during hypotensive period.Results BRS was reduced in groups of N,U and C after intubation compared with that before(P<0.05 or P<0.01),which was lower in grouP N than that in group C,but was higher in group E than that in group C at all time points(P<0.05).Conclusion The induction of general anesthesia may reduce BRS in EH patients.which is aggravatedby preinjection of nicardipine.Urapidil has no effect on BRS,but esmolol may increase BRS during induction of general anesthesia.
