Progress in the research on 21-gene Oncotype Dx in breast cancer prognosis
- VernacularTitle:21基因Oncotype Dx对乳腺癌预后研究的进展
- Author:
Ning LIAO
;
Xuchao ZHANG
- Publication Type:Journal Article
- Keywords:
breast cancer;
21-gene Oncotype Dx;
prognosis;
prediction
- From:
China Oncology
2009;19(12):953-958
- CountryChina
- Language:Chinese
-
Abstract:
Currently the most effective treatment strategy for breast cancer is standardized multi-discipline comprehensive treatment. However, there are no effective models that can accurately predict prognosis, so that no guidance of individualized treatment has yet been set up, resulting in a proportion of patients with low risk who received chemotherapy with little benefit. With the development of genomics, several gene sets have been demonstrated to be helpful in predicting of breast cancer prognosis and grading the patients' benefit from chemotherapy, thus avoid overtreatment. 21-gene Oncotype Dx was reported as one of them and has been demonstrated to be effective and accurate in various clinical studies. This paper summarizes researches on 21-gene Oncotype Dx in breast cancer.
