Effect of Exercise on the Interleukin-1 beta(IL-1β) Expression in Muscle Tissue of Insulin-Resistant Rats
- VernacularTitle:运动干预对胰岛素抵抗大鼠骨骼肌IL-1β表达的影响
- Author:
Huimin WANG
;
Jian DU
;
Lina PEI
;
Juan WANG
;
Feng WU
;
Xiangyang LIU
;
Lina GUAN
;
Zhinan LIN
- Publication Type:Journal Article
- Keywords:
Exercise;
Insulin resistance;
Interrleukin-1 beta;
Muscle;
Rats
- From:
Acta Laboratorium Animalis Scientia Sinica
2009;17(6):437-441
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of swimming exercise on insulin sensitivity and interleukin-1 beta(IL-1β)mRNA expression in muscle tissue of insulin-resistant (IR) rats induced by high-fat diet.Methods The IR rat model was induced by high-fat diet feeding for 10 weeks and assessed by hyperinsulinemic-euglycemic clamp technique (HEC). The rats were divided into the fllowing three groups: normal group without exercise, IR groups with and without swimming exercise. After 4 weeks swimming excersie, insulin sensitivity and serum IL-1β levels were measured.Results Glucose infusion rate (GIR) of the IR rats was significantly elevated than that of non-exercise IR rats (P<0.01). Moreover, serum IL-1β levels were reduced markedly in IR rats (P<0.01). Conclusion High-fat diet feeding can partly reverse IR of rats to normal value. Swimming exercise improves insulin sensitivity and reduces the levels of IL-1β in IR rats induced by high-fat diet.
