Morphology and Immunohistochemistry of Sarcomatoid Carcinoma of the Fallopian Tube
10.3870/j.issn.1672-0741.2009.06.015
- VernacularTitle:输卵管肉瘤样癌形态学及免疫组化观察
- Author:
Guizhu WU
;
Xiu ZHENG
;
Linying CHEN
;
Yihong CHENG
;
Yilu ZOU
;
Zhongqing JIANG
- Publication Type:Journal Article
- Keywords:
sarcomatoid carcinoma;
carcinoma of the fallopian tube;
immunohistochemistry
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2009;38(6):779-783
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pathologic morphology and immunohistochemical phenotypes of sarcomatoid carcinoma(SC) of the fallopian tube.Methods One case of SC of the fallopian tube was studied under the light microscopy for morphology.Immunohistochemistry was used to detect the expression of CK,EMA,S-100,Desmin,SMA,Leu-7,CD68,actin,and Vimentin in SC tissues.Pathologic features and biological behaviors of SC were analyzed in combination with the review of literature.Results Microscopically carcinomatous and sarcomatous elements co-existed.Usually the sarcomatous element formed the bulk of the lesion.In the sarcomatous tissues,there was no distinguishable bone,cartilage,rhadomyosarcoma,etc. Immunohistochemically the strong expression of CK7,EMA and Vimentin,and the partial expression of S-100,SMA,Leu7,CD68 and actin were detected.Conclusion SC of the fallopian tube is lack of specific symptoms,and its preoperative diagnosis is difficult.B-ultrasonography,CT and MRI are helpful to the staging of SC.Final diagnosis of SC depends on pathological examination and immunohistochemistry.SC is rare,and undergoes blood metastasis in early stage.Prognosis of SC is worst.Early detection of SC is the key to improve the prognosis.
