Progress in Research of the Role of Hepatitis C Virus Protein in Cell Signal Transduction Pathway
- VernacularTitle:丙型肝炎病毒蛋白作用于细胞信号转导途径的研究进展
- Author:
Mei XUE
;
Jiejie DAI
;
Xueshan XIA
- Publication Type:Journal Article
- Keywords:
Hepatitis C virus;
Cell signal transduction;
Core protein;
Envelope protein E2;
Nonstructural protein NS3;
Nonstructural protein NS5A;
1 Cell signal transduction
- From:
Acta Laboratorium Animalis Scientia Sinica
2009;17(6):470-474
- CountryChina
- Language:Chinese
-
Abstract:
Abnormal cell signal transduction is associated with the occurrence and development of human diseases. Some virus pathogenicity and infection mechanism are due to virus antigen protein acting on the host cell signal transduction pathway, leading to host cell signal transduction disorder. Hepatitis C virus (HCV) is a major pathogen of chronic hepatitis C, which causes cirrhosis and hepatocellular carcinoma. But the pathogenesis of HCV and persistent infection mechanism remain far from clear. HCV pathogenesis may be related to the HCV protein expression interfering host cell signal transduction pathways. The studies of hepatitis C virus proteins acting on host cell signal transduction pathways, not only help to clarify the impact of its pathogenic mechanisms, but also benefit to new drug design and development for new treatment methods. This article summarizes the recent progress in research on the effect of hepatitis C virus protein in cell signal transduction pathways in the past few years.
