Clinical significance of IgG determination in children with Henoch-Schonlein purpura

VernacularTitle:小儿过敏性紫癜尿IgG测定的临床意义
Author: Xiaowei WANG ; Tianying ZHONG ; Yong CHANG
Publication Type:Journal Article
Keywords: Purpura; schoenlein-henoch; Urine t Immunoglobulin G; Clinical laboratory techniques
From: International Journal of Laboratory Medicine 2009;30(12):1171-1172
CountryChina
Language:Chinese
Abstract: Objective To investigate the role of IgG determination in diagnosis of early renal damage in children with Henoch-schonlein purpura(HSP). Methods Urine IgG was determined in 188 children with HSP (HSP group), 99 patients with Henoch-schonlein purpura nephritis (HSPN group) and 26 healthy controls (healthy control group). Simultaneously, qualitative detection of urine protein was carried out in HSP group. Results The abnormality rate of urine IgG was significantly higher than that of urine protein in HSP group (P<0. 05). The level of urine IgG was significantly higher in HSP group than that in healthy control group (P<0. 05), while the level of urine IgG in group than that in HSP group (P<0. 05). Conclusion Urine IgG determination is simple and nonin-vasive, which if high clinical value in diagnosis of early renal damage in children with Henoch-schonlein purpura(HSP).