Relationships of concentrations of true insulin, proinsulin to coronary heart disease: a preliminary study
- VernacularTitle:血清真胰岛素、胰岛素原与冠心病关系初探
- Author:
Xiaofen LIU
;
Lixiang LIN
;
Mingqin CHEN
- Publication Type:Journal Article
- From:
Chinese Journal of Endocrinology and Metabolism
2001;17(2):87-89
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine serum true insulin (TI) and proinsulin (PI) levels in patients with coronary heart disease (CHD), and to explore the relationships of them to other cardiovascular risk factors. Methods Highly specific ELISA assays for TI and PI and RIA for immunoreactive insulin (IRI) were used. The fasting serum IRI, TI, PI levels in 30 nondiabetic patients with CHD and 30 healthy, age-matched control subjects were investigated. And the fasting and 2h postprandial plasma glucose, serum lipids and blood pressure were also determined in each individuals. Results The levels of serum IRI, TI and PI were significantly higher in patients with CHD than those in controls (P＜0.05), while the value of insulin sensitivity index (ISI) was lower in patients with CHD than in controls (P＜0.05). There were significant independent correlations between TI, PI and age, BMI, plasma glucose, serum lipids. Conclusion Nondiabetic patients with CHD have hyperinsulinemia and insulin resistance and there is an independent association between proinsulin and dyslipidemia.
