Marburg I polymorphism of Factor Ⅶ-activating protease and cerebral infarction
- VernacularTitle:FⅦ活化蛋白酶基因的Marburg I 型多态性与脑梗死发病的相关性
- Author:
Qian TAN
;
Huarong TANG
;
Rongrong LIU
;
Guangping WANG
;
Xiaosu YANG
;
Fangping CHEN
- Publication Type:Journal Article
- Keywords:
FactorⅦ-activating protease;
Marburg I polymorphism;
cerebral infarction;
single strand conformation polymorphism-polymerase chain reaction
- From:
Journal of Central South University(Medical Sciences)
2009;34(12):1171-1175
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the relation between Marburg I polymorphism of FactorⅦ-activating protease (FSAP) and cerebral infarction,and to analyze whether it is one of the risk factors of cerebral infarction.Methods Single strand conformation polymorphism-polymerase chain reaction (SSCP-PCR) was applied for the polymorphism analysis of FSAP in 159 patients with cerebral infarction and 179 non-cerebral infarction subjects.Results The phenotypes of FSAP in both the patients and the control subjects were wild type GG;no mutant of Marburg I was found. But a new gene mutation was tested, which had not been reported, requiring further investigation. Conclusion Marburg I polymorphism of FSAP may not be associated with cerebral infarction.
