Determination of Musk Xylene in Cosmetics by Solid Phase Extraction-Isotope Dilution-Gas Chromatography Tandem Mass Spectrometry
- VernacularTitle:固相萃取-同位素稀释-气相色谱-串联质谱法测定化妆品中的二甲苯麝香
- Author:
Qiang MA
;
Hua BAI
;
Chao WANG
;
Wei MA
;
Qing ZHANG
;
Haiqing XIAO
;
Xin ZHOU
;
Yiyang DONG
;
Baolin WANG
- Publication Type:Journal Article
- Keywords:
Solid phase extraction;
isotope dilution;
gas chromatography tandem mass spectrometry;
cosmetics;
musk xylene
- From:
Chinese Journal of Analytical Chemistry
2009;37(12):1776-1780
- CountryChina
- Language:Chinese
-
Abstract:
A comprehensive analytical method based on solid phase extraction-isotope dilution-gas chromatography tandem mass spectrometry has been developed for the determination of musk xylene in cosmetics. Various cosmetic samples, including cream, lotion, powder, shampoo and lipstick, were extracted under ultrasonication. The extract was centrifuged, and the upper solution was concentrated by rotary evaporator. The reconstructed solution was then cleaned up by Sep-Pak Silica solid phase extraction cartridge. Qualitative and quantitative analysis was carried out under the MRM mode after the chromatographic separation on DB-5 MS(30 m×0.25 mm, 0.25 μm) capillary column. The limit of quantitation(LOQ) for musk xylene was 5 μg/kg. The mean recoveries at the three spiked levels of 5-50 μg/kg were 81.1%-86.9%, with the intra-day precision less than 10% and the inter-day precision less than 12%. The method is accurate, rapid, sensitive and adapt to the inspection of musk xylene in cosmetics.
