Progress on the relationship between genetic polymorphism of CYP2D6 and endocrine therapy of breast cancer
- VernacularTitle:CYP2D6基因多态性与乳腺癌内分泌治疗
- Author:
Ping ZHANG
;
Shiyang GU
;
Wenxin QIN
;
Xichun HU
- Publication Type:Journal Article
- Keywords:
CYP 2D6;
genetic polymorphism;
tamoxifen metabolism;
endocrine therapy;
breast cancer
- From:
China Oncology
2009;19(12):959-962
- CountryChina
- Language:Chinese
-
Abstract:
CYP2D6 is one of the cytochrome P450 isozymes which are involved in the metabolism of various drugs with wide use. Polymorphism at the CYP2D6 locus is one of the most widely known causes for pharmacogenetic variability in humans beings. This review focuses on the importance of CYP2D6 polymorphism in the metabolism of tamoxifen, relationships between the genetic polymorphism and prognosis of patients who have underwent endocrine therapy, and evidences indicating that CYP2D6 may be used as a predictive marker for choosing optimal endocrine therapy for patients with breast cancer.
