Progress in research on mechanisms of bone metastasis in breast cancer
- VernacularTitle:乳腺癌骨转移机制研究进展
- Author:
Hui CHEN
;
Zan SHEN
- Publication Type:Journal Article
- Keywords:
breast cancer;
bone metastasis;
molecular mechanisms
- From:
China Oncology
2009;19(12):963-968
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer ranks among the most prevalent malignancies in women. Specific aspects of both breast cancer cells and the bone microenvironment contribute to the development of bone metastases. Breast cancers express chemokine receptors, integrins, cadherins, and bone-resorbing and bone-forming factors that contribute to the successful and preferential spread of tumor from breast to bone. Bone is rich in growth factors and cell types that make it a favorable environment for breast cancer cell growth. Once breast cancer cells enter the bone, breast cancer cells can secrete factors that act on bone cells and other cells within the bone, causing them to secrete factors that act on adjacent cancer cells. The steps in the metastatic cascade and the vicious cycle within bone offer unique targets for adjuvant treatments to treat and cure bone metastasis.
