Comparison between Changchun'an sustained-release capsules and Nimodipine for the treatment of vascular cognitive impairment
10.3969/j.issn.1673-8225.2009.47.039
- VernacularTitle:长春胺缓释胶囊治疗血管性认知功能障碍:与尼莫地平的对照
- Author:
Haitao CHI
;
Rui JIN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(47):9369-9372
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To compare the therapeutic effect of Changchun'an sustained-release capsules and Nimodipine tablets on the treatment of vascular cognitive impairment.METHODS: A total of 120 patients with vascular cognitive impairment were randomly divided into treatment group and control group, with 60 patients for each group. Patients In the treatment group were treated with Changchun'an sustained-release capsules, 30 mg for each administration, twice a day; the other patients in the control group were treated with Nimodipine tablets,30 mg for each administration, 3 times a day. The treatment course was 6 months for both groups. The scores of clinical efficiency,Mini-Mental State Examination (MMSE), and Activity of Daily Living Scale (ADL) were analyzed.RESULTS: The total effective rates of Changchun'an sustained-release capsules and Nimodipine tablets were 60.0% and 53.3%,respectively, and there was significant difference in the total effective rates between treatment and control groups (P < 0.05). The scores of MMSE and ADL in both groups were improved obviously after treatment compared with before treatment (P < 0.01),and there was a significant difference between the two groups after treatment (P < 0.05). The side effects of Changchun'an sustained-release capsules were obviously posterior to those of Nimodipine tablets.CONCLUSION: Changchun'an sustained-release capsules are effective in treating vascular cognitive impairment with few side effects.
