Comparison of biocompatibility between degradable and nondegradable drug eluting stents
10.3969/j.issn.1673-8225.2009.48.024
- VernacularTitle:可降解与非可降解药物洗脱支架生物相容性的差异比较
- Author:
Yanmei WU
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(48):9507-9510
- CountryChina
- Language:Chinese
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Abstract:
OBJECTIVE: To study the problems following implantation of nondegradable drug eluting stent, and to investigate the biocompatibility of degradable stent. METHODS: Articles were retrieved from CNKI and Pubmed with the key words of "degradable, drug-eluting stent, compatibility" in both Chinese and English from January 1999 to June 2009. Indicators including biocompatibility, endothelialization degree of coronary artery, and incidence of in-stent restenosis were evaluated. Articles related to degradable drug eluting stent were included, while articles related to other types of stent were excluded. RESULTS: Among 236 articles, 33 articles were included in the final analysis. Recently, drug stents consist of nondegradable polymer, which will be ageing and falling into small blocks in the vessels and may induce adverse effect, following long-term human body corrosion. However, degradable materials may reduce onset of adverse effect in later stage. Degradable stent may temporarily support vessel wall, smoothly keep blood flow, inhibit thrombosis in an eedy stage and newbom endomembrane proliferation in later stage, and effectively prevent acute vascular occlusion and reduce incidence of restenosis following stent implantation. CONCLUSION: Compared with nondegradable stent, degradable drug eluting stent has a great biocompatibility and a hopeful perspective.
