Effects of esomeprazole and omeprazole on clopidogrel platelet inhibition following cardiac stent implantation
10.3969/j.issn.1673-8225.2009.52.016
- VernacularTitle:埃美索拉唑和奥美拉唑对心脏支架置入后氯吡格雷抗血小板作用的影响
- Author:
Qian GUO
;
Wen JIN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(52):10283-10286
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the effects of omeprazole and esomeprazole,two kinds of proton pump inhibitors,on clopidogrel platelet inhibition following cardiac stents implantation.METHODS:Totally 180 patients with coronary artery disease underwent percutaneous coronary intervention (PCI) at the Zhujiang Hospital of Southern Medical University from June 2008 to May 2009 were selected,including 83 males and 97 females.All patients were randomly divided into 3 groups,omeprazole + clopidogrel + aspirin group (OCA group,receiving omerprazole 20 mg/d),esomeprazole+clopidogrel+aspirin group (ECA group,receiving esomeprazole 10 mg/d),and control group (No proton pump inhibitor),with 60 patients in each group.In addition,all patients received a 300 mg clopidogrel and 0.1 g aspirin prior to PCI,and received 75 mg/d clopidogrel and 100 mg/d aspirin treatment for 1 week after PCI.Blood samples from patients were obtained from cubital vein before and at 1 week after adminstration,respectively.The vasodilator stimulated phosphoprotein phosphorylation state and platelet reactivity index (PRI) were calculated by flow cytometric assay.RESULTS:The PRI had no significant difference before administration (P>0.05),which was obviously decreased at 1 week after administration (P<0.05),especially lowest in the control and ECA groups (P<0.05).However,the PRI differences between the control and the ECA group had no significant (P>0.05).CONCLUSION:The administration of omeprazole rather than esomeprazole is associated with impaired clopidogrel platelet inhibition.Esomeprazole can be used as one of the preferred proton pump inhibitor in curing gastrointestinal bleeding caused by anti-platelet therapy following cardiac stents implantation.
