Cancer stem cells and stem cells: Source, differentiation and their correlation

VernacularTitle:肿瘤干细胞与干细胞:来源、分化及其相关性
Author: Bin LING ; Jing CHEN ; Jie SUN
Publication Type:Journal Article
From: Chinese Journal of Tissue Engineering Research 2009;13(49):9743-9746
CountryChina
Language:Chinese
Abstract: Cancer stem cells are a new field with the gradual deep understanding of the stem cell research. Although its history is not long, the rapid development showed a good potential prospect. The existence of cancer stem cells and its use as tumor formation, growth and metastasis-based approach has been widely recognized. In theory, cancer stem cells derived from normal stem cells can transform. Cancer-causing factors can also be derived-from the dedifferentiation induced cells. Because it contains all-round, multi-and single stem cell, with the proliferation and differentiation potential of different directions, it is possible to explain the heterogeneity of tumor cells, and reasons for hypoxic environment, anti-cancer drugs and radiation resilience. In this area, it has been made a lot of progress in recent years. However, there are still some problems to be solved. Such as the identification of cancer stem cells, biological function and mechanism.