Effects of perforated bovine amnion combined with recombinant bovine basic fibroblast growth factor on degree Ⅱ burn wounds A comparison with imperforated bovine amnion and vaseline gauze dressing
10.3969/j.issn.1673-8225.2009.51.043
- VernacularTitle:有孔牛羊膜联合重组牛碱性成纤维细胞生长因子覆盖Ⅱ度烧伤创面:与无孔牛羊膜及凡士林纱布的比较
- Author:
Hua GUO
;
Guoshi XU
;
Botao WANG
;
Mingxin QIU
;
Zhijun ZHU
;
Jiaxiang KE
;
Jing ZHAO
;
Qingjian XU
;
Jiade YUAN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(51):10193-10196
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To observe the clinical effect of perforated bovine amnion combined with recombinant bovine basic fibroblast growth factor (rb-bFGF) on degree Ⅱ burn wounds.METHODS: A total of 43 patients with small and medium-size thermal burn were collected, and the area of testing wound was 1% -2%. The wounds with the same nature were divided into three groups: perforated bovine amnion (treatment group), bovine amnion (control 1 group), and vaseline gauze dressing (control 2 group). All the three groups combined with rb-bFGF. RESULTS: Compared with control 1 group (P < 0.01) and control 2 group (P < 0.05), the treatment group could obviously decrease the healing time of deep degree Ⅱ burn wounds. For superficial degree Ⅱ burn wounds, compared with the control 2 group, the treatment group could also decrease the healing time; however, there was no significant difference between treatment group and control 1 group (P > 0.05). Dressing was not changed frequently, and the pain was relieved. Rash or other adverse effects were not detected in the three groups.CONCLUSION: The combination of perforated bovine amnion and rb-bFGF can obviously promote the healing of burn wounds.
