ADF/cofilins proteinic family constellation in cytoskeletal protein:How does depolymerization occur through combination of ADF/cofilins with actin?

VernacularTitle:细胞骨架蛋白中ADF/cofilin蛋白家系的作用:如何与肌动蛋白结合及发挥解聚作用?
Author: Lei TIAN ; Mingfang LIAO ; Futing JIANG ; Xuedong CHEN ; Yuhong WANG
Publication Type:Journal Article
From: Chinese Journal of Tissue Engineering Research 2009;13(50):9941-9945
CountryChina
Language:Chinese
Abstract: The actin depolymerizing factor/cofilin (ADF/cofilins) are a family of actin-binding proteins expressed in all eukaryotic cells. The ADF/cofilins appear to have multiple functions, and this is reflected in their very complex association with both monomeric and filamentous actin. Phosphorylation by some kinases and other factors such as LIM kinases 1 and 2, TESK 1 and TESK 2 kinase, Insulin, etc, prevents ADF/cofllins from binding actin. The serial researchs of ADF/cofilins are increasingly becoming study hot spots, especially on the relationship between homo-sapiens disease and mechanism of action of ADF/cofilins.Now in this domain wilderness details are still far from clear, such as the mechanism by which actin filaments are depolymerized by ADF/cofilins has been controversial.