CXCR4 and vascular endothelial growth factor expressions in esophageal squamous cell cancer and their correlations
- VernacularTitle:食管鳞形细胞癌组织中CXCR4和血管内皮生长因子表达的相关性研究
- Author:
Chunlai LU
;
Di GE
;
Qun WANG
- Publication Type:Journal Article
- Keywords:
esophageal cancer;
CXCR4;
vascular endothelial growth factor
- From:
Fudan University Journal of Medical Sciences
2010;37(1):25-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlations of the expressions of CXCR4 and vascular endothelial growth factor (VEGF) in esophageal cancer and their associations with patients' clinicopathological features.Methods The paraffin-embedded samples of 127 patients with esophageal cancer treated by thoracic surgery in Zhongshan Hospital in 2005 were collected. The CXCR4 and VEGF expressions in esophageal cancer tissues were detected with immunohistochemical technique. The immunostaining was evaluated according to the staining area and intensity. Results The overall expression rate was 88.2% and 79.5%, respectively. CXCR4 expression was significantly associated with tumor grade, size, tumor depth, regional lymph node metastasis and TNM stage (P<0.05);VEGF expression was significantly associated with tumor depth, TNM stage and tumor grade.In addition, there were significant correlations between CXCR4 and VEGF (P<0.01). Conclusions There was significant association between CXCR4, VEGF expressions and clinicopathological features of esophageal cancer. There might be some potential correlation between CXCR4 and VEGF expression in esophageal cancer.
