Endcapping of Octadecyl Bonded Silica by Atomic Layer Deposition for Separation of Basic Compounds
- VernacularTitle:十八烷基键合硅胶的原子层沉积法封尾及其在碱性化合物分离中的应用
- Author:
Zhiqiang GUO
;
Lei CHEN
;
Qianhong WAN
- Publication Type:Journal Article
- Keywords:
Reversed phase liquid chromatography;
octadecyl bonded silica;
endcapping;
atomic layer deposition;
basic compounds
- From:
Chinese Journal of Analytical Chemistry
2009;37(11):1572-1576
- CountryChina
- Language:Chinese
-
Abstract:
Atomic layer deposition has been employed for postsynthesis treatment of octadecyl bonded silica (ODS) as a typical reversed-phase stationary phase for high performance liquid chromatography (HPLC) ,in an effort to alleviate peak tailing for basic compounds. With hexamethyldisilazane( HMDS) as an endcapping agent,the ODS packing materials were heated to 250℃,and maintained at that temperature for 6 h,affording packing materials which are highly inert to basic compounds. Chromatographic performance in terms of retention factor and tailing factor of the resulting phases was evaluated using phenol/pyridine and naphthalene/ami-triptyline pairs as probes. The results were compared with those for the same packing treated by liquid phase method and for the commercial products including Zorbax SB-C_(18) and Kromasil C_(18). The separation characteristics of the ODS phase obtained by atomic layer deposition appear to be superior to that by liquid phase method and,comparable with or even better than the commercial products studied. Being solvent-free process amenable to mass production,the described method provides an economical and eco-friendly approach to manufacturing HPLC packing materials on industrial scale.
