Effect of ranolazine on the fast sodium channel current in rabbit atrial myocytes and use-dependent blockade
- VernacularTitle:雷诺嗪对兔心房肌细胞快钠电流的影响及使用依赖性阻滞作用
- Author:
Xianqing WANG
;
Jiaying ZHANG
;
Ganxin YAN
;
Cuntai ZHANG
;
Chuanyu GAO
;
Changcun CUI
- Publication Type:Journal Article
- Keywords:
ranolazine;
fast sodium channel current (INa);
use-dependence;
late sodium current
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
2010;31(1):63-66
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of ranolazine on the fast sodium channel current (INa) in rabbit atrial myocytes and the existence of use-dependent blockade. Methods Standard whole cell patch clamp technique was used to study the effect of ranolazine on the fast sodium channel current and the use-dependent blockade caused with different frequencies (1Hz, 3.3Hz and 5Hz) to stimulate the cells. Results The 30μmol/L ranolazine significantly reduced INa with an IC_(50) value of (25.6±1.8)μmmol/L and produced a frequency-dependent inhibitory effect on INa with obvious use-dependence. Conclusion Ranolazine can inhibit the fast sodium channel current in rabbit atrial myocytes and indeed has a use-dependent effect.
