The expression and clinical significance of mTOR/P70S6K signaling pathway in cervical cancer
- VernacularTitle:mTOR/P70S6K信号通路在宫颈癌组织中的表达及其临床意义
- Author:
Jing JI
;
Tingting GU
;
Pengsheng ZHENG
- Publication Type:Journal Article
- Keywords:
cervical cancer;
mammalian target of rapamycin (mTOR);
P70S6K
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
2010;31(1):10-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression and function of mammalian target of rapamycin (mTOR) and its substrate kinase P70S6K in mTOR/P70S6K signal pathway in cervical carcinogenesis. Methods The expression of mTOR and P70S6K in normal cervix uteri or cervical cancer was detected by the immunohistochemistry and RT-PCR methods. Results Compared to those in normal cervix uteri, both mRNA and protein of mTOR/P70S6K in cervical carcinomas were significantly increased (P<0.05). There was a positive correlation between mTOR gene and P70S6K gene expression in cervical cancer (r=0.746, P<0.001). Conclusion High expression of mTOR and P7OS6K may play an important role in the pathogenesis and development of cervical cancer.
