Characteristics and methods of super-hydrophobic surface anticoagulation property study
10.3969/j.issn.1673-8225.2009.51.023
- VernacularTitle:国内外超疏水表面抗凝血性能研究的方法特征
- Author:
Wewei LIN
;
Mingqiang ZHONG
;
Jie FENG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(51):10113-10116
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: The super-hydrophobic surface exhibits excellent super-hydrophobic property, which attracts more attention in anti-coagulation property study. However, the test result is differing from the expectation.OBJECTIVE: To summarize the research status of super-hydrophobic effects on anti-coagulation.METHODS: The web of science database was retrieved with key words of "super-hydrophobic surface; blood compatibility; platelet adhesion; protein adsorption" to search papers concerning anti-coagulation property of super-hydrophobic surface. A total of 37 papers were initially searched by computer. According to the inclusive criteria, 20 papers were initially in this review. RESULTS AND CONCLUSION: Through thorough analyzing different test methods of platelet adhesion used by present researchers, including in vitro static platelet adhesion, in vitro blood circulation experiments and in vivo animal experiments, we find that it may be not accurate and objective to obtain the conclusion of the super-hydrophobic surface possessing positive effect on anti-coagulation only by statically testing platelet adhesion in vitro. In order to confirm whether the super-hydrophobic luminal surface has anti-coagulating property, analysis of the blood deposition onto the luminal surface after in vitro circulation experiments and in vivo implantation experiments must be performed.
