Nursing management with alemtuzumab for prevention of graft rejection
10.3969/j.issn.1673-8225.2009.53.045
- VernacularTitle:新型移植诱导剂阿来佐单抗临床应用中的护理程序
- Author:
Fang LUO
;
Zhixian WU
;
Xiaoqin TAO
;
Liting HUANG
;
Jinquan CAI
;
Junqi GUO
;
Peikuan JIANG
;
Jianming TAN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(53):10597-10600
- CountryChina
- Language:Chinese
-
Abstract:
Alemtuzumab (Campath) was successfully injected in 21 kidney transplant patients,7 islet transplant patients and 1 simultaneous kidney and islet transplant patient for either prevention or treatment of graft rejection.Prophylactic administration was successfully completed in all patients without discontinuation.Adverse events were not observed in 11 patients (38%),but hypertension in 18 patients (62%),shivering in 3 patients (10.3%),high fever in 3 patients (10.3%),and bronchospasm in 1 patient (3%),respectively.All complications alleviated after proper therapy.During the prophylactic administration of alemtuzumab,strict,timely and proper ward-management was needed.Care for lung,perineum,skin,diet and psychological nursing were necessary.Neither graft acute rejection nor graft chronic rejection episode occurred in all patients during 6 months to 2 years follow-up.Therefore,long term effects of Alamtuzumab and consequences of lymphocytopenia need further observation.
