Advancement of pretreatment to decrease antigenicity in homologous nerve transplantation
10.3969/j.issn.1673-8225.2009.53.027
- VernacularTitle:同种异体神经移植去抗原性的预处理:应用与前景
- Author:
Xinsheng LIU
;
Wei WANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(53):10525-10528
- CountryChina
- Language:Chinese
-
Abstract:
Autogenous nerve transplantation is the best means for treating peripheral nerve injury. However, it would detriments function of donor area. Therefore, homologous nerve transplantation is adopted in clinic. The key of successful nerve allograft transplantation is to reduce nerve allograft antigenicity. Compared to physics method, chemistry method achieved a better result in reducing antigenicity of allograft nerve. Here, we introduce immune response and characteristics of grafts following homologous nerve transplantation, discuss the pretreatment method which can reduce the antigenicity. And propose that the combination of one or many kinds of methods would decrease the antigenicity of homogenous nerve in future.
