Clinical treatment of spinal cord injury with olfactory ensheathing cells transplantation
10.3969/j.issn.1673-8225.2009.53.029
- VernacularTitle:嗅鞘细胞移植治疗脊髓损伤的临床研究现状
- Author:
Nongshan ZHANG
;
Peimin WANG
;
Jianfeng LI
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(53):10533-10536
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To introduce the present research situation of treating spinal cord injury using olfactory ensheathing cells (OECs) transplantation from the aspects of biological characteristics, culture, purify of OECs and its application.DATA SOURCES: PubMed database and Chinese Journal Full-text Database were retrieved with key words of "olfactory ensheathing cells, spinal cord injury" from 2000 to 2009. DATA SELECTION: Inclusion criteria: ①The literature was closely associated with OECs and spinal cord injury. ②Literatures about the same circle published in the near future or on the authoritative journals. Exclusion criteria: ①Repetitive study. ②Meta analysis.RESULTS: OECs has similar characteristics to Schwann cells and astrocytes. At present, the research about OECs includes axonal regeneration, cellular replacement, demyelinating prevention and so on. Furthermore, some clinical experiment had been carried on. However, some difficulties exist in clinical trials, such as transplantation dose of OECs, activity of cell factor and transplant risk. We need to do further study on OECs transplantation and more follow up after cells graft. Some research had tried to transplant with gene transfer cells, and satisfactory results were obtained.CONCLUSION: With the development of genetic engineering and research of OECs transplantation, OECs transplantation must bring more hope to patients with spinal cord injury.
