Efficacy and safety of postoperative non-steroidal antiinflammatory drugs therapy in patients following total hip arthroplasty:A Meta analysis
10.3969/j.issn.1673-8225.2009.52.003
- VernacularTitle:全髋关节置换术后应用非类固醇类抗炎药有效性和安全性的荟萃分析
- Author:
Hongwu MA
;
Genyuan CHEN
;
Denghai MI
;
Long HU
;
Weihua HOU
;
Guoxin QU
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2009;13(52):10223-10226
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:The non-steroidal antiinflammatory drugs (NSAIDs) were widely used to prevent heterotopic bone formation following total hip arthroplasty (THA),however,its efficacy and safety is poorly understood.OBJECTIVE:To determine the efficacy and safety of postoperative NSAIDs therapy in patients undergoing THA using Meta analysis.METHODS:The databases of PubMed,Embase,Cochrane Library,Chinese biomedical literature,CNKI,VIP as well as bibliographies of retrieved articles were researched for randomized controlled trials comparing NSAID versus control after THA,and the data were analyzed using Review Manager 5.0.RESULTS AND CONCLUSION:A total of 13 randomized controlled trials totaling 4706 participants were included.The result of meta analysis showed that low dose aspirin did not significantly affect the incidence of heterotopic bone formation (HBF) [RR=0.99,95% CI (0.87,1.14) rather than medium to high dose NSAIDs [RR=0.44,95% CI(0.30,0.64),there was no significant difference between two group in hip pain and physical function,the incidence of HBF was 16.0% in NSAID-group and 11.1% in 7 Gy group.Apart from low dose aspirin,medium to high doses of postoperative NSAIDs produce a substantial reduction in the incidence of HBF at the cost of minor high gastrointestinal side effect.Limited evidence showed there were no significant differences between the groups for improvements in hip pain and physical function,7 Gy fraction is more effective than use of NSAID.
