Clinical Investigation of Lower-extremity Arterial Disease in Patients with Newly Diagnosed Type 2 Diabetes Mellitus Combined with Nonalcoholic Fatty Liver Disease
- VernacularTitle:新诊断2型糖尿病合并非酒精性脂肪肝患者下肢动脉粥样硬化的临床分析
- Author:
Xiaofei ZHANG
;
Yanming CHEN
;
Yan SUN
;
Manman WANG
;
Shengqing HE
;
Jiong SHU
;
Guochao ZHANG
;
Longyi ZENG
- Publication Type:Journal Article
- Keywords:
type 2 diabetes mellitus;
nonalcoholic fatty liver disease;
lower-extremity arterial disease;
insulin resistant
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2010;31(1):134-137
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To investigate the clinical characteristics and risk factors of lower-extremity arterial disease in the patients with newly diagnosed type 2 diabetes mellitus combined with nonalcoholic fatty liver disease (NAFLD). [Methods] One hundred fifty-one patients were investigated respectively. The patients were divided into two groups (NAFLD-Group and non-NAFLD group) by liver ultrasonography and disease history, then their clinical data were collected and compared in order to find the differences of biochemical indicators and the morbidity of lower-extremity arterial disease between two groups. [Results] Ninety-two cases (60.93%) were complicated with NAFLD. NAFLD group had higher levels of fast insulin and C peptide level, postprandial insulin and C peptide level, uric acid, body mass index (BMI), homeostasis model assessment (HOMA-IR) and lower level of high-density lipoprotein cholesterol and insulin sensitive index than those of without NAFLD (P<0.05). One hundred and one cases(66.89%) were complicated with lower-extremity arterial disease. The morbidity of lower-extremity arterial diseases was higher in NAFLD group than that of without NAFLD group (75% vs. 54.24%, P<0.01). [Conclusion] Both lower-extremity arterial disease and NAFLD are common complicated with type 2 diabetes. The morbidity of lower-extremity arterial diseases was higher in NAFLD group than that of without NAFLD group.
