Expression and ultrastructure location of PPAR-γ and COX-2 in endometrial carcinoma
10.3969/j.issn.0529-1356.2010.01.022
- VernacularTitle:过氧化物酶体增殖因子激活受体γ、环氧合酶-2在子宫内膜癌中的表达及超微结构定位
- Author:
Haiyan BIAN
;
Yuanyuan LI
;
Hongjuan WU
;
Yuqing LIU
- Publication Type:Journal Article
- Keywords:
PPAR-γ;
COX-2;
Endometrial carcinoma;
Immunohistochemistry;
Colloidal gold immunoelectron microscopy technique;
Human
- From:
Acta Anatomica Sinica
2010;41(1):114-118
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the development and prognosis of peroxisome proliferator-activated recepor-γ(PPAR-γ) and cyclooxygenase-2(COX-2) in endometrial carcinoma. Methods The electron microscopic immunohistochemical technique was used to observe the ultrastructure location of COX-2 protein labeled by colloidal gold in the endometrial carcinoma. Results 1.There were negative immunohistochemical staining signals of PPAR-γ in both the normal endometrium and hyperplasia endometrium, whereas, was positive staining in the endometrial carcinoma;2.The intensities of the COX-2 immunohistochemical staining were significantly statistical difference among the normal endometrium, the hyperplasia endometriu and the endometrial carcinoma(P<0.01);3. The COX-2 labelled by colloidal gold granules was observed in the endoplasmic reticulum, nuclear membrane and nuclei in the endometrial carcinoma. Conclusion Both PPAR-γ and the COX-2 might play an important role in the development of the endometrial carcinoma.
