Retention Behavior of Acid Drugs in Microemulsion Liquid Chromatography
- VernacularTitle:酸性药物在微乳液相色谱体系中的保留行为
- Author:
Jiehua SHI
;
Ting LI
;
Xiaohui ZHOU
- Publication Type:Journal Article
- Keywords:
Microemulsion liquid chromatography;
Retention modeling;
Retention behavior;
Naproxen;
Ibu profen;
Diclofenac;
Phenylalanine;
2,4-Dichlorophenoxy acetic acid
- From:
Chinese Journal of Analytical Chemistry
2010;38(1):27-32
- CountryChina
- Language:Chinese
-
Abstract:
The retention mechanism of acid drugs such as naproxen, ibuprofen, diclofenac, phenylalanine and 2,4-dichlorophenoxy acetic acid in microemulsion liquid chromatography has been discussed.The reten tion modeling between capacity factors (k') of acid drugs in microemulsion liquid chromatography and concen tration of surfactant, cosurfactant and lipophilic organic solvent and pH value was set.The results showed the effect of change of concentration of surfactant, cosurfactant and lipophilic organic solvent and pH value on capacity factors of acid drugs in microemulsion liquid chromatography was fully consistent with the theoretical modeling.The retention modeling can better reflect the effect of composition of microemulsion solution and pH value on retention behavior of acid drugs in microemulsion liquid chromatography.
