The study on the expression of NF-κB in tumor associated inflammatory tissues in patients with adamantinomatous craniopharyngima
- VernacularTitle:核转录因子κB在颅咽管瘤炎症中的表达
- Author:
Guanglong HUANG
;
Songtao QI
;
Jia LI
;
Jun PAN
;
Baoguo LIU
;
Wei MENG
;
Yongming ZHANG
;
Luxiong FANG
- Publication Type:Journal Article
- Keywords:
Craniopharyngioma Inflammation NF-κB Osteopontin CRP
- From:
Chinese Journal of Nervous and Mental Diseases
2010;36(1):39-42
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate Nuclear factor-κB (NF-κB) expression in tumor associated inflammation in patients with adamantinomatous craniopharyngima..Methods Fifty-four patients (31 male and 23 female) with craniopharyngioma from 3 to 66 years of age were recruited from May 2004 to March 2006.NF-κB and Osteopontin (OPN) expression in human craniopharyngiomas were detected using immunohistochemical staining.High-sensitivity C-reactive protein (hs-CRP), a systemic marker of inflammation, was examined in patients' tumor hydatid fluid, cerebrospinal fluid and serum.Results NF-κB expression was significantly increased in the adamantinomatous craniopharyngioma.Spearman;s correlation analysis demonstrated that NF-κB expression was associated with OPN expression.The hs-CRP level was also increased in the tumor hydatid fluid (4.28±0.90 mg/mL), cerebrospinal fluid (0.035±0.006 mg/mL) and serum (1.72±0.54 mg/mL) in patients with adamantinomatous craniopharyngioma.Conclusions NF-kappa B is closely associated with tumor associated inflammation which further mediates adhesion of tumor to surrounding important structures in patients with adamantinomatous craniopharyngioma.
