Pharmacokinetics and tissue distribution of deferiprone in rats
10.3867/j.issn.1000-3002.2010.01.010
- VernacularTitle:去铁酮在大鼠体内的药代动力学与组织分布
- Author:
Quanquan GONG
;
Ping LIU
;
Yanan ZHANG
;
Hualei XU
;
Yucai LI
;
Xiaojing JIA
- Publication Type:Journal Article
- Keywords:
deferiprone;
chromatography,high-performance liquid;
pharmacokinetics
- From:
Chinese Journal of Pharmacology and Toxicology
2010;24(1):59-63
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the pharmacokinetics and tissue distribution of deferiprone (DFP) in rats. METHODS Plasma and tissues were collected after male Wistar rats were ig given DFP 35, 70 and 140 mg·kg~(-1) at different time points. The DFP in plasma and tissues was determined by high performance liquid chromatography. The compartment model was fitted and pharmacokinetic parameters were calculated by DAS 2.0. RESULTS The results showed that the pharmacokinetic process of DFP in rats was two-compartment model after rats were ig given DFP 35, 70 and 140 mg·kg~(-1). The t_(1/2α) were 23.3, 22.2 and 20.9 min, respectively. The t_(1/2β) were 53.3, 50.9 and 46.3 min, respectively. The Cl were 0.017, 0.021 and 0.016 L·min~(-1)·kg~(-1), respectively. The content of DFP was high in stomach and liver tissues after rats were ig given DFP 70 mg·kg~(-1), and it was lower in the other tissues. The content of DFP in liver tissues was (359.22±31.16)μg·g~(-1), at 60 min after rats were ig given DFP 70 mg·kg~(-1). CONCLUSION The absorption and elimination of DFP are quick and the tissue distribution of DFP is wide in vivo.
