Mechanism underlying intrauterine growth retardation induced by caffeine and its research advance

VernacularTitle:咖啡因致胎儿宫内发育迟缓机制的研究进展
Author: Shu ZHOU ; Jing HUANG ; Chong BAO ; Jie PING ; Hui WANG
Publication Type:Journal Article
Keywords: intrauterine growth retardation; caffeine; fetus; developmental disabilities
From: Chinese Journal of Pharmacology and Toxicology 2010;24(1):77-80
CountryChina
Language:Chinese
Abstract: Intrauterine growth retardation (IUGR) is one of the most commonly encountered developmental toxicity, which could lead to perinatal morbidity and mortality, be also extended from the fetus to adulthood, and seriously affect the quality of the population. Caffeine widely exists in a variety of daily beverages and some drugs. Its consumption is increasing year by year. Caffeine intake during pregnancy is one of the risk factors for IUGR. However, its mechanism of adverse outcome based on embryonic research is still unclear. In this paper, the possible mechanisms of caffeine-induced IUGR focusing on 3 important factors-the mother, placenta and fetus were explored. Caffeine's impact on the mother is the chronic activation of renin-angiotensin system; on the placenta, caffeine induces cell damage or the failure of the cell proliferation/apoptosis balance, leading to blockage of blood supply to the placenta; caffeine is also capable of directly affecting fetal development through interfering its neuroendocrine.