Roles of regulatory T cell in tumor immunity and tumor immunotherapy

VernacularTitle:调节性T细胞在肿瘤免疫和肿瘤免疫治疗中的作用
Author: Yizhi YU ; Xuetao CAO
Publication Type:Journal Article
Keywords: regulatory T cell(Treg); neoplasms; immune escape; immunotherapy
From: Chinese Journal of Cancer Biotherapy 2010;17(1):1-6
CountryChina
Language:Chinese
Abstract: There are multiple types of inhibitory immune cells in tumor. Among these cells, Treg (regulatory T cell) plays an extremely important role in tumor development and progression. Treg exihibits potent inhibitory effects on effector cells by a variety of mechanisms, which might be the the key factor for tumor immune escape. These mechanisms include inhibiting the effector cell function by inhibitory cytokines, killing effector cells by granzyme and profrin, interfering effector cell metabolism, and affecting Treg differentiation and proliferation by regulating the function of dendrtic cells, etc. The research on Treg has provided new strategies for tumor immunotherapy. Tumor immunotherapies targeting Treg and related immunosuppressive factors, such as deleting Treg nonsepcificlly or sepcificlly controling the numbers and functions of Treg, might have a bright future in clinical application.keyword regulatory T cell(Treg); neoplasms; immune escape; immunotherapy