Progress in the study of G-quadruplex telomerase inhibitors
- VernacularTitle:具抑制端粒酶活性的G-四链体小分子配体研究进展
- Author:
Yanmei LI
;
Xiaoyan SHEN
- Publication Type:Journal Article
- Keywords:
G-quadruplex;
telomerase inhibitor;
micromolecular ligands;
DNA;
oncogene;
anti-tumor drugs
- From:
Chinese Pharmacological Bulletin
2010;26(1):17-20
- CountryChina
- Language:Chinese
-
Abstract:
Telomerase can inhibit the shortening of telomere and stimulate continuous cell proliferation to form tumor.The activity of telomerase can be prohibited by G-quadruplex formed by the single chain in G-rich field of telomere 3' end, resulting in tumor cell apoptosis.Ligands which can induce the formation or stabilize the structure of G-quadruplex in G-rich field of oncogene exhibit antitumor function. Nowadays it becomes the core concern of chemists and biologists to screen and structurally design the compounds targeting G-quadruplex.This paper summarized the discoveries in the G-quadruplex-targeted telomerase inhibitors in recent years.
