Identification of 5 Novel Y Chromosome STR Loci and Haplotype Distribution in Chinese Han Population (Guangzhou)
- VernacularTitle:5个新Y-STR基因座及其在广州地区汉族群体内的单倍型分布
- Author:
Yunliang ZHU
;
Yanmei HUANG
;
Jianjin LI
;
Xinyao WU
- Publication Type:Journal Article
- Keywords:
STR typing;
Y chromosome;
short tandem repeats;
haplotype;
Chinese Han population
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2010;31(1):7-12
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To screen and identify the new Y-STR loci from the Y chromosome and examine the polymorphism of these Y-STR loci. [Method] To seek and locate the position of 5 Y-STR loci, including DYS709, DYS720, DYS721, DYS722, and DYS723, and perform sequencing of these 5 Y-STR loci. Then to investigate the polymorphism in unrelated Chinese Han males. [Results] Five Y-STR loci were identified from Y chromosome sequence. By scrutinizing the physical position on Y chromosome of previously reported Y-STRs, we found that three loci were novel and two loci overlapped with two loci published only online. All loci could be male-specifically amplified with a product size ranging from 185 bp to 278 bp. After 108 males of the Chinese Han Population (Guangzhou) were examined, we found 5 DYS709, 11 DYS720 alleles, 4 DYS721 alleles, 6 DYS722 alleles, and 6 DYS723 alleles. A total of 95 haplotypes were identified, 84 of which were unique, and with a haplotype diversity of 0.997 2±0.001 2(HD±SE). [Conclusion] This set of Y-STRs can be used as Y chromosome genetic makers in related fields.
